Synthese von 1α‐Hydroxycholecalciferol. Vorläufige Mitteilung
作者： Andor Fürst , Ludvik Labler , Werner Meier , Karl-Heinz Pfoertner
关键词: Diacetyl 、 Medicinal chemistry 、 Saponification 、 Polymer chemistry 、 Derivative (chemistry) 、 Chemistry 、 Isomerization
摘要: 1α-hydroxycholesterol (4a) was synthesized from cholesterol and transformed via its diacetyl derivative 4b into 1α, 3β-diacetoxycholesta-5, 7-diene (6b). Irradiation of the ring-B-diene 6b followed by thermal isomerization saponification gave 1α-hydroxycholecalciferol (7).
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