Weight reduction and pharmacologic treatment in obese hypertensives.

摘要: This study was conducted to evaluate the mechanisms of weight loss-induced blood pressure (BP) reduction focusing, in particular, on contributions sympathetic nervous system activity, fasting plasma insulin, and leptin BP levels, delineate additional influence antihypertensive drug therapy. Each five groups obese hypertensives were treated with long-acting calcium channel blocker (CCB) amlodipine, angiotensin converting enzyme (ACE) inhibitor enalapril or without a program, program alone. The goal less than 140/90 mm Hg for pharmacologic treatment groups. divided into two groups; loss who succeeded (> = 10%) nonweight failed ( (<10%). reductions NE, significantly greater earlier combined alone In ACE groups, especially other CCB group, insulin occurred, but there no change NE. Reductions occurred later group. These results show that associated favorable metabolic improvements these are amplified when treatment. Therefore, should be regarded as an essential component any obesity-related hypertension. A novel finding from this is inhibition had striking effect lower leptin. Suppression insulinemia, leptinemia appeared play role accompanying loss.