Noninvasive Diagnostics for Portal Hypertension: A Comprehensive Review.

摘要: Noninvasive diagnostics for portal hypertension include imaging and functional tests, as well blood-based biomarkers, capture different features of the hypertensive syndrome. Definitive conclusions regarding their clinical utility require assessment diagnostic value in specific settings (i.e., diagnosing a particular hemodynamic condition within well-defined target population). Several noninvasive methods are predictive clinically significant (CSPH; hepatic venous pressure gradient [HVPG] ≥ 10 mm Hg; threshold complications hypertension); however, only minority them have been evaluated compensated advanced chronic liver disease Importantly, most correlate weakly with HVPG at high values patients CSPH). Nevertheless, selected show promise HVPG ≥ 16 mm Hg (the cut-off increased risks decompensation mortality) monitoring changes response to nonselective beta-blockers or etiological treatments. Finally, we review established potential future applications methods.