Monoamine Oxidase Inhibitors, Tyramine, and Cheese
作者： David Horwitz , Walter Lovenberg , Karl Engelman , Albert Sjoerdsma
DOI: 10.1001/JAMA.1964.03060390010002
关键词: Hydrochloride 、 Tranylcypromine 、 Medicine 、 Pharmacology 、 Monoamine oxidase 、 Phentolamine 、 Tyramine 、 Nialamide 、 Toxicity 、 Phenelzine
摘要: Marked potentiation of the pressor effects tyramine hydrochloride, given orally and intravenously, was demonstrated in patients receiving a monoamine oxidase (MAO) inhibitor. Assays content various foods revealed up to 25μg/ml wine 1.4 mg/gm some cheeses. As little as 20 gm cheese produced responses which were controllable with phentolamine methane-sulfonate MAO-inhibited patients. These findings extend previous work on mechanism toxicity emphasize one hazards treatment MAO inhibitors.
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