New drug targets for type 2 diabetes and the metabolic syndrome
作者： David E. Moller
DOI: 10.1038/414821A
关键词: Lipotoxicity 、 Metabolic syndrome 、 Biology 、 Internal medicine 、 Type 2 diabetes 、 Diabetes mellitus 、 Insulin resistance 、 Bioinformatics 、 Obesity 、 Disease 、 Insulin 、 Endocrinology
摘要: … in the absence of defined molecular targets or an understanding of disease pathogenesis. … has led to a host of new molecular drug targets. Several have been validated through genetic …
harvard.edu
nature.com
sci-hub.se 
utoronto.ca 参考文章(71)
Goodyear Lj, AMP-activated protein kinase: a critical signaling intermediary for exercise-stimulated glucose transport? Exercise and Sport Sciences Reviews. ,vol. 28, pp. 113- ,(2000)
Neil B. Ruderman, Asish K. Saha, Demetrios Vavvas, Lee A. Witters, Malonyl-CoA, fuel sensing, and insulin resistance American Journal of Physiology-endocrinology and Metabolism. ,vol. 276, ,(1999) , 10.1152/AJPENDO.1999.276.1.E1
Anders H. Berg, Terry P. Combs, Xueliang Du, Michael Brownlee, Philipp E. Scherer, The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nature Medicine. ,vol. 7, pp. 947- 953 ,(2001) , 10.1038/90992
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine. ,vol. 7, pp. 941- 946 ,(2001) , 10.1038/90984
Serge Clément, Ulrike Krause, Florence Desmedt, Jean-François Tanti, Jens Behrends, Xavier Pesesse, Takehiko Sasaki, Joseph Penninger, Margaret Doherty, Willy Malaisse, Jacques E. Dumont, Yannick Le Marchand-Brustel, Christophe Erneux, Louis Hue, Stéphane Schurmans, The lipid phosphatase SHIP2 controls insulin sensitivity Nature. ,vol. 409, pp. 92- 97 ,(2001) , 10.1038/35051094
Claire M. Steppan, Shannon T. Bailey, Savitha Bhat, Elizabeth J. Brown, Ronadip R. Banerjee, Christopher M. Wright, Hiralben R. Patel, Rexford S. Ahima, Mitchell A. Lazar, The hormone resistin links obesity to diabetes Nature. ,vol. 409, pp. 307- 312 ,(2001) , 10.1038/35053000
David E. Moller, Douglas A. Greene, Peroxisome proliferator-activated receptor (PPAR)γ agonists for diabetes Drug Discovery and Design. ,vol. 56, pp. 181- 212 ,(2001) , 10.1016/S0065-3233(01)56006-4
Christian A. Baumann, Neel Chokshi, Alan R. Saltiel, Vered Ribon, , Cloning and Characterization of a Functional Peroxisome Proliferator Activator Receptor-γ-responsive Element in the Promoter of the CAP Gene Journal of Biological Chemistry. ,vol. 275, pp. 9131- 9135 ,(2000) , 10.1074/JBC.275.13.9131
N Cohen, M Halberstam, P Shlimovich, C J Chang, H Shamoon, L Rossetti, Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation. ,vol. 95, pp. 2501- 2509 ,(1995) , 10.1172/JCI117951
Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, Brad R. Henke, The PPARs: from orphan receptors to drug discovery. Journal of Medicinal Chemistry. ,vol. 43, pp. 527- 550 ,(2000) , 10.1021/JM990554G