Pharmacotherapy of critical limb ischaemia

摘要: Peripheral arterial disease is a frequent cause of morbidity. Five percent men in the United Kingdom over age 50 years suffer from its most common symptom, intermittent claudication [54]. Critical ischaemia which threatens limb survival develops approximately 12% [58]. The second European Consensus Document on critical (CLI) [37] describes clinical CLI as patients who have persistent recurring rest pain requiring regular analgesia for greater than 2 weeks and/or ulceration or gangrene foot toes. An ankle systolic pressure > mmHg further, though debated, requirement. A fundamental process pathogenesis development atherosclerosis causing narrowing occlusion proximal blood vessels reduces flow and perfusion to distal circulation. This primary problem leads changes microcirculation described below.