Impact of obesity on metabolic syndrome components and adipokines in prepubertal children.
作者： Isabel R Madeira , Cecilia NM Carvalho , Fernanda M Gazolla , Liana W Pinto , Marcos A Borges
DOI: 10.2223/JPED.1873
关键词: Insulin 、 Adipokine 、 Leptin 、 Blood sugar 、 Obesity 、 Endocrinology 、 Adiponectin 、 Medicine 、 Insulin resistance 、 Metabolic syndrome 、 Internal medicine
摘要: Objective: To verify the impact of obesity on metabolic syndrome components and adipokine levels in prepubertal children. Methods: This cross-sectional study compared 30 obese, 31 overweight 33 eutrophic children attending a university hospital-based outpatient pediatric clinic. Parameters assessed included glucose, serum lipids, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), glucose/insulin relation, adiponectin, leptin. We frequency acanthosis nigricans changes waist, blood pressure, insulin. The correlation between body mass index (BMI) z score adipokines was evaluated. Results: Among obese children, there difference mean values HDL cholesterol whereas among HOMA-IR, leptin (p < 0.001). A also observed regarding alteration waist 0.005) group. BMI showed positive with 0.001) negative adiponectin = In multiple linear regression, this maintained only for leptin; HDL-cholesterol correlated 0.007) HOMA-IR both variables 0.05). Conclusion: These findings provide evidence influence indicating that these may contribute to beginning cardiovascular diseases.
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