Sulfoxide‐Directed Stereocontrolled Access to 2H‐Chromans: Total Synthesis of the (S,R,R,R)‐Enantiomer of the Antihypertensive Drug Nebivolol
作者： M. Carmen Carreño , Gloria Hernández-Torres , Antonio Urbano , Françoise Colobert
关键词: Sulfoxide 、 Deoxygenation 、 Enantiomer 、 Nebivolol 、 Stereoselectivity 、 Antihypertensive drug 、 Enantioselective synthesis 、 Stereochemistry 、 Total synthesis 、 Organic chemistry 、 Chemistry
摘要: A homochiral sulfoxide-directed reductive deoxygenation of 2-(p-tolylsulfinyl)methyl-2-chromanols allows the stereoselective formation 2H-chromans with up to 95:5 diastereoisomeric ratio. This new methodology was appliedin a short and convergent enantioselective synthesis ofthe (S,R,R,R)-enantiomer antihypertensive drugNebivolol.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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