First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers.
作者： K. Spencer , I. Staboulidou , K. H. Nicolaides
DOI: 10.1002/PD.2445
关键词: Prenatal diagnosis 、 Obstetrics 、 Pregnancy-associated plasma protein A 、 Gestational sac 、 Gynecology 、 Pregnancy 、 Trisomy 、 Vanishing twin 、 Singleton 、 Crown-rump length 、 Medicine
摘要: Objective To assess the impact of a vanishing twin on levels biochemical markers used in first trimester aneuploidy screening. Methods A retrospective analysis free β-hCG and PAPP-A 270 women with normal singleton fetus ultrasound evidence pregnancy. Marker (as MoM) were compared three groups—76 second empty gestational sac, 194 sac containing dead measurable crown rump length (CRL), 1360 matched pregnancies. Results In median MoMs (0.968 1.040, respectively) not significantly different from 1.0 MoM pregnancies. In group vanished measurable—CRL—there was increased (1.317) but changed (1.024). Modelling this bias detection rate for trisomy 21 would fall 85 to 75%. Conclusion First screening presence may lead errors risk estimation. such circumstances it be advisable restrict use nuchal translucency (NT) alone. Copyright © 2009 John Wiley & Sons, Ltd.
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