Repeat Mild Traumatic Brain Injury in Adolescent Rats Increases Subsequent β-Amyloid Pathogenesis.

摘要: Abstract Single moderate-to-severe traumatic brain injuries (TBIs) may increase subsequent risk for neurodegenerative disease by facilitating β-amyloid (Aβ) deposition. However, the chronic effects on Aβ pathogenesis of repetitive mild TBIs (rTBI), which are common in adolescents and young adults, remain uncertain. We examined rTBI sustained during adolescence deposition pathology a transgenic APP/PS1 rat model. Transgenic rats received sham or four individual (rTBIs) separated either 24- 72-h intervals at post-natal day 35 (before plaque deposition). Animals were euthanized 12 months age underwent immunohistochemical analyses Significantly greater hippocampal was observed after 24 h relative to 72 h injuries. These increases load driven both number size. Similar, though less-pronounced, effects...