Characterization of CTL Recognized Epitopes on Human Breast Tumors
作者： Constantin G. Ioannides
DOI: 10.21236/ADA383880
关键词: Cytotoxic T cell 、 Antigen 、 Epitope 、 Biology 、 Ovarian cancer 、 Cancer research 、 Immunology 、 Ovarian tumor 、 Metastasis 、 CTL* 、 Tumor antigen
摘要: Abstract : The overall objective of this proposal is to develop novel therapeutic approaches breast cancer by understanding the molecular and cellular basis tumor antigen (Ag) recognition cytotoxic T lymphocytes (CTL). Characterization HLA-A2 bound peptides comparison CTL activity signal intensity mass-spectrometry has lead identification a Ag, defined peptide epitope from amino-enhancer split (AES) protein. This protein part "Notch" complex involved in regulation cell fate during development. Ag recognized both ovarian reactive lines. Studies on HER-2 optimization have also led design clinical trial with E75: (369 - 377) for patients cancer. To address significance these epitopes we are currently exploring ability corresponding induce specific immunity.
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