Targeting the angio-proteostasis network: Combining the forces against cancer

摘要: The VEGF family of pro-angiogenic factors has represented a pillar for targeted cancer therapy more than decade. In comparison, the field protein homeostasis (proteostasis) focusing on Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, just recently emerged as attractive anti-cancer approach. Recent findings suggest that both pathways are incontestably interrelated to ensure cell survival. Herein, we summarize recent demonstrate how these two fundamental aspects survival intersect and provide genetic pharmacological evidence interplay between angiogenic such VEGF-A or PlGF individual members UPR IRE1, PERK ATF6. We further describe this interaction does not only affect cells, but also surrounding microenvironmental niche is involved in tumor progression. Furthermore, by summarizing therapeutic implications anti-angiogenic proteostatic approaches, emphasize novel could be used synergistically improve therapy.