Long-term outcome of pediatric liver transplantation for biliary atresia: a 10-year follow-up in a single center.

摘要: The aim of this study was to review our experience in orthotopic liver transplantation (OLT) for biliary atresia (BA) children and analyze the survival prognostic factors, long-term outcome. We reviewed 332 OLTs performed 280 between years 1986 2000. Univariate multivariate analysis were on patient graft survivals according recipients' donors' characteristics as well intraoperative data. outcome among 80 living at 10 after OLT studied growth, immunosuppressive therapy, renal functions. Liver status eventually documented by biopsy. Status rehabilitation assessed reviewing school performance employment. Overall rates 1, 5, 85, 82, 82%, respectively, corresponding overall 77, 73, 71%. In analysis, we identified 4 independent factors: polysplenia syndrome (P = .03), United Network Organ Sharing (UNOS) .05), donor's age .01), perioperative surgical complications .03). At transplant, alive had normal growth rates. histology abnormal 73% these survivors, mainly due chronic rejection centrilobular fibrosis. A total 63 attended 55 (69%) not delayed. conclusion, discovered that a good could be achieved BA, with 82% rate scholastic studies majority recipients.