Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages
作者： C. Scheibenbogen , G. Zenke , B. Faggs , K. Motoyoshi , L. Kanz
DOI: 10.1007/978-3-642-75510-1_6
关键词: Haematopoiesis 、 Mononuclear phagocyte system 、 Granulocyte colony-stimulating factor receptor 、 Cell biology 、 Biology 、 Macrophage-activating factor 、 Immunology 、 Macrophage 、 Colony-stimulating factor 、 Adipose tissue macrophages 、 Granulocyte
摘要: Cells of the mononuclear phagocyte system (MPS) are involved in immune surveillance against microbial pathogens and malignant cells but also important regulator hematopoiesis [1, 2]. They able to secrete a variety factors that suppress or sitmulate proliferation differentiation hematopoietic progenitor cells. Of these, macrophage colony-stimulating factor (M-CSF) granulocyte-CSF have been shown be released from monocytes [3], whereas synthesis GM-CSF is disputed [3, 4]. However, undergo maturation into macrophages acquire functional competence which significant vivo [5–7].
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