Manganese neurotoxicity and the role of reactive oxygen species
作者： Ebany J. Martinez-Finley , Claire E. Gavin , Michael Aschner , Thomas E. Gunter
DOI: 10.1016/J.FREERADBIOMED.2013.01.032
关键词: Chemistry 、 Radical 、 Oxidative stress 、 Antioxidant 、 Reactive oxygen species 、 Manganese 、 Manganism 、 Biochemistry 、 Neurotoxicity 、 Mitochondrion 、 Physiology (medical)
摘要: Manganese (Mn) is an essential dietary nutrient, but excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure of Mn and due to the production reactive oxygen species, free radicals, toxic metabolites; alteration mitochondrial function ATP production; depletion cellular antioxidant defense mechanisms. This review focuses on all preceding mechanisms scientific studies that support them well providing overview absorption, distribution, excretion stability transport compounds in body.
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