“One Swallow Does Not Make a Summer” … or Does It?

摘要: Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA. Ann Neurol 2007;61(5):411–426. OBJECTIVE: The contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode neonatal (sNS) on rat postnatal day (P) 7 permanently impairs hippocampal-dependent function in mature (P60) rats because long-lasting at synaptic level. METHODS: sNS was induced with subcutaneously injected kainate P7. Learning, memory, mossy fiber sprouting, spine density, hippocampal plasticity, and glutamate receptor expression subcellular distribution were measured P60. RESULTS: selectively impaired working memory radial arm water-maze task without inducing sprouting or altering density. CA1 long-term potentiation enhanced depression. Subcellular fractionation cross-linking, used determine whether trafficking underlies alterations demonstrated selective reduction membrane pool 1 subunits. decrease total amount N-methyl-d-aspartate 2A an increase primary subsynaptic scaffold, PSD-95. INTERPRETATION: These molecular consequences are consistent plasticity caused by Our data demonstrate impact associate deficits specific glutamatergic function.