Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

摘要: The helper-dependent pathway of priming CD8(+) T cells involves "licensing" DCs by CD40L on CD4(+) cells. helper-independent ("helpless") pathways elicited many viruses, including influenza, are less widely understood. We have postulated that can be up-regulated such and this promotes via CD40. Most studies costimulation been performed in the presence cells, so role under helpless circumstances has not fully elucidated. Here, we investigated a for using KO mice. Although number influenza-specific was unaffected absence it markedly decreased CD40L. Proliferation (the CD44(+)BrdU(+) cells) primary response diminished mice at Day 8 but 5 after infection. MLR indicated expression critical cell activation. Adoptive transfer CD40 compared with WT confirmed generation anti-influenza responses. late effect also corresponded suggest is important optimizing responses during influenza