The PACE trial of treatments for chronic fatigue syndrome: a response to WILSHIRE et al.
作者： Michael Sharpe , Kim Goldsmith , Trudie Chalder
DOI: 10.1186/S40359-019-0288-X
关键词: Physical function 、 Medical research 、 Graded exercise therapy 、 Pace 、 Physical therapy 、 Cognitive behaviour therapy 、 Psychology 、 Clinical trial 、 Psychological research 、 Chronic fatigue syndrome
摘要: Chronic Fatigue Syndrome (CFS) is chronic disabling illness characterized by severe fatigue, typically made worse exertion. Myalgic Encephalomyelitis (ME) thought some to be the same disorder (then referred as CFS/ME) and others different. There an urgent need find effective treatments for CFS. The UK Medical Research Council PACE trial published in 2011 compared available concluded that when added specialist medical care, cognitive behaviour therapy graded exercise were more improving both fatigue physical function participants with CFS, than adaptive pacing specialised care alone. In this paper, we respond methodological criticisms of a reanalysis data reported Wilshire at al. We conclude neither nor offer any convincing reason change conclusions trial.
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