Brain metabolite differences in one-year-old infants born small at term and association with neurodevelopmental outcome

摘要: Objective We assessed brain metabolite levels by magnetic resonance spectroscopy (MRS) in 1-year-old infants born small at term, as compared with appropriate for gestational age (AGA), and their association neurodevelopment at 2 years of age. Study Design A total 40 (birthweight 1 H-MRS) data were acquired from the frontal lobe short echo time. Neurodevelopment was evaluated using Bayley Scales Infant Toddler Development, Third Edition, assessing cognitive, language, motor, social-emotional, adaptive behavior scales. Results As AGA controls, showed significantly higher glutamate N-acetylaspartate (NAAt) to creatine (Cr) ratio year, lower Edition scores years. The subgroup late intrauterine growth restriction further estimated glutathione year. Significant correlations observed scores, myo-inositol language scores. associations also noticed NAA/Cr cognitive glutamate/Cr motor Conclusion Infants show differences year age, which are correlated later neurodevelopment. These results support research on MRS develop imaging biomarkers abnormal