Inflammation and Hras signaling control epithelial–mesenchymal transition during skin tumor progression

摘要: Epithelial–mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process tumor dissemination and metastasis. About 20%–30% Hras mutant mouse skin carcinomas induced by chemical initiation/promotion protocols have undergone EMT. Reduced exposure TPA-induced chronic inflammation causes a dramatic reduction in classical papillomas squamous cell (SCCs), but mice still develop highly invasive with EMT properties, reduced levels Egfr signaling, frequent Ink4/Arf deletions. Deletion from germline also leads strong development, tumors now acquire activating Kras mutations exhibit more aggressive metastatic properties. We propose that can arise different genetic biological routes dependent on target populations within skin. Our data implications for use inhibitors or Ras/Egfr pathway signaling prevention treatment cancers.