Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas.

摘要: Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% alone 21% S. otitis media. Among the that after inoculation both pneumococcus influenza, 73% affected ears contained effusion, 27% showed tympanic membrane inflammation without middle ear effusion obtained on paracentesis. Although a majority yielded culture, one-third effusions were sterile for aerobic bacteria. This model resembles conditions accompanying humans suggests respiratory viral infection contributes significantly to pathogenesis acute