Aspirin Drug Intercalated into Zinc-Layered Hydroxides as Nanolayers: Structure and In Vitro Release
作者： Nisreen Abdul Rahman Najem Abed , Suha Mujahed Abudoleh , Iyad Daoud Alshawabkeh , Abdul Rahman Najem Abed , Rasha Khaled Ali Abuthawabeh
DOI: 10.4028/WWW.SCIENTIFIC.NET/NHC.18.42
关键词: Materials science 、 Aspirin 、 In vitro 、 Zinc 、 Organic chemistry 、 Drug
摘要: Zinc layered hydroxides (ZLHs) can be used as host materials for drug-ZLH host–guest structures. Aspirin with 0.1 and 0.4 M were intercalated into zinc layered hydroxides to form aspirin nanocomposites; ASPN1 and ASPN4, respectively. From XRD and software, the interlayer spacing of ASPN1 and ASPN4 was 15.2 Å. The result coupled with molecular geometry calculation indicates that the spatial orientation of the drug in the ZLH was monolayer for ASPN1 and ASPN4 nanocomposites. The release of the aspirin from ASPN4 nanocomposite at pH 6.8 is 35%, compared to 98% at pH 1.2, and followed Hixson model and Korsmeyer model for ASPN4 at pH 6.8 and pH 1.2, respectively. This result indicates sustained release of the drugs from their respective nanocomposites, and therefore these nanocomposites have good potential to be used as controlled-release formulation of the aspirin. The ASPN4 nanocomposite was highly effective to Escherichia coli compared to free aspirin, where the ASPN4 given 1.37 inhibition zone compared to aspirin which given 1.17 cm inhibition zone.
omicsonline.org 参考文章(41)
Mohd Zobir Hussein, Samer Hasan Al Ali, Zulkarnain Zainal, Muhammad Nazrul Hakim, None, Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent International Journal of Nanomedicine. ,vol. 6, pp. 1373- 1383 ,(2011) , 10.2147/IJN.S21567
Marek Boczar, Marek J. Wójcik, Krzysztof Szczeponek, Dorota Jamróz, Adam Zięba, Bożena Kawałek, THEORETICAL MODELING OF INFRARED SPECTRA OF ASPIRIN AND ITS DEUTERATED DERIVATIVE principles and practice of constraint programming. ,vol. 286, pp. 63- 79 ,(2003) , 10.1016/S0301-0104(02)00912-6
Ozge Altuntasoglu, Yuki Matsuda, Shintaro Ida, Yasumichi Matsumoto, None, Syntheses of Zinc Oxide and Zinc Hydroxide Single Nanosheets Chemistry of Materials. ,vol. 22, pp. 3158- 3164 ,(2010) , 10.1021/CM100152Q
Amelia M. Avachat, Vijay G. Patel, Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability Journal of The Saudi Pharmaceutical Society. ,vol. 23, pp. 276- 289 ,(2015) , 10.1016/J.JSPS.2014.11.001
Lun Dong, Li Yan, Wan-Guo Hou, Shao-Jie Liu, Synthesis and release behavior of composites of camptothecin and layered double hydroxide Journal of Solid State Chemistry. ,vol. 183, pp. 1811- 1816 ,(2010) , 10.1016/J.JSSC.2010.05.035
Soon-Jae Kwon, Jin-Ho Choy, A novel hybrid of Bi-based high-Tc superconductor and molecular complex. Inorganic Chemistry. ,vol. 42, pp. 8134- 8136 ,(2003) , 10.1021/IC034755T
A.K. Hilton, P.B. Deasy, In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate International Journal of Pharmaceutics. ,vol. 86, pp. 79- 88 ,(1992) , 10.1016/0378-5173(92)90033-X
Yiyun Cheng, Tongwen Xu, The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs. European Journal of Medicinal Chemistry. ,vol. 43, pp. 2291- 2297 ,(2008) , 10.1016/J.EJMECH.2007.12.021
Tatsuo Ishikawa, Kumi Matsumoto, Kazuhiko Kandori, Takenori Nakayama, Anion-exchange and thermal change of layered zinc hydroxides formed in the presence of Al(III) Colloids and Surfaces A: Physicochemical and Engineering Aspects. ,vol. 293, pp. 135- 145 ,(2007) , 10.1016/J.COLSURFA.2006.07.018
I.G. Binev, B.A. Stamboliyska, Y.I. Binev, The infrared spectra and structure of acetylsalicylic acid (aspirin) and its oxyanion: an ab initio force field treatment Journal of Molecular Structure. ,vol. 378, pp. 189- 197 ,(1996) , 10.1016/0022-2860(95)09170-X