Contribution to investigation of antimicrobial activity of styrylquinolines.
作者： Wioleta Cieslik , Robert Musiol , Jacek E. Nycz , Josef Jampilek , Marcela Vejsova
DOI: 10.1016/J.BMC.2012.10.027
关键词: Bacitracin 、 Bacteria 、 Ciprofloxacin 、 Antimicrobial 、 Staphylococcus 、 Chemistry 、 Organic chemistry 、 Penicillin 、 Antibacterial activity 、 Lipophilicity
摘要: Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared characterized. The compounds analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening the synthesized was performed against fungal bacterial strains. Some active bacteria at micromolar level fungi submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than standard fluconazole as well antibacterial Staphylococcus strains standards bacitracin, penicillin ciprofloxacin. structure-activity relationships are discussed.
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