作者: Daniel Antunes Silva Pereira , Alexandre de Melo Kawassaki , Bruno Guedes Baldi
DOI: 10.1590/S1806-37132013000600012
关键词: Biopsy 、 Autoantibody 、 Interstitial lung disease 、 Medicine 、 Lung 、 Pathology 、 Idiopathic interstitial pneumonia 、 Connective tissue disease 、 Autoimmunity 、 Differential diagnosis 、 Immunology
摘要: The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest presence rheumatic disease, are routinely performed at various referral centers. When involvement is condition that allows definitive diagnosis connective tissue and classical criteria met, there little debate. However, still debate regarding significance, relevance, specificity, pathophysiological role autoimmunity in predominant pulmonary only mild symptoms or formes frustes disease. purpose this article was to review current knowledge autoantibody positivity discuss its possible interpretations ILD without clear etiologic associations, as well enhance understanding natural history an allegedly new describe prognostic implications. We also proposition term be used classification ILDs: lung-dominant