Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease

作者: Daniel Antunes Silva Pereira , Alexandre de Melo Kawassaki , Bruno Guedes Baldi

DOI: 10.1590/S1806-37132013000600012

关键词: BiopsyAutoantibodyInterstitial lung diseaseMedicineLungPathologyIdiopathic interstitial pneumoniaConnective tissue diseaseAutoimmunityDifferential diagnosisImmunology

摘要: The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest presence rheumatic disease, are routinely performed at various referral centers. When involvement is condition that allows definitive diagnosis connective tissue and classical criteria met, there little debate. However, still debate regarding significance, relevance, specificity, pathophysiological role autoimmunity in predominant pulmonary only mild symptoms or formes frustes disease. purpose this article was to review current knowledge autoantibody positivity discuss its possible interpretations ILD without clear etiologic associations, as well enhance understanding natural history an allegedly new describe prognostic implications. We also proposition term be used classification ILDs: lung-dominant

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