Alkylphospholipids and Leishmaniasis

M.J. McConville, T.A. Collidge, M.A. Ferguson, P. Schneider, The glycoinositol phospholipids of Leishmania mexicana promastigotes : evidence for the presence of three distinct pathways of glycolipid biosynthesis Journal of Biological Chemistry. ,vol. 268, pp. 15595- 15604 ,(1993) , 10.1016/S0021-9258(18)82298-0

Consuelo Gajate, Faustino Mollinedo, Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells Current Drug Metabolism. ,vol. 3, pp. 491- 525 ,(2002) , 10.2174/1389200023337225

Pallavi Wadhone, Moitrayee Maiti, Reena Agarwal, Vanita Kamat, Sunil Martin, Bhaskar Saha, Miltefosine promotes IFN-γ-dominated anti-Leishmanial immune response Journal of Immunology. ,vol. 182, pp. 7146- 7154 ,(2009) , 10.4049/JIMMUNOL.0803859

Guadalupe Miró, Gaetano Oliva, Israel Cruz, Carmen Cañavate, Michele Mortarino, Claudia Vischer, Paolo Bianciardi, Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis Veterinary Dermatology. ,vol. 20, pp. 397- 404 ,(2009) , 10.1111/J.1365-3164.2009.00824.X

Jaime Soto, Jaime Ardiles, Julia Toledo, Jaime Rea, Jonathan Berman, Luis Valda, Margarita Valderrama, Efficacy of extended (six weeks) treatment with miltefosine for mucosal leishmaniasis in Bolivia American Journal of Tropical Medicine and Hygiene. ,vol. 81, pp. 387- 389 ,(2009) , 10.4269/AJTMH.2009.81.387

Belén Martín-Martín, Manuel Modolell, Faustino Mollinedo, Adalberto Benito, Consuelo Gajate, Jose Luis Fernández-Luna, Rosa Martínez-Dalmau, Selective Induction of Apoptosis in Cancer Cells by the Ether Lipid ET-18-OCH3 (Edelfosine): Molecular Structure Requirements, Cellular Uptake, and Protection by Bcl-2 and Bcl-XL Cancer Research. ,vol. 57, pp. 1320- 1328 ,(1997)

M J McConville, M A J Ferguson, The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochemical Journal. ,vol. 294, pp. 305- 324 ,(1993) , 10.1042/BJ2940305

Marta Mateo, Laurence Maynard, Claudia Vischer, Paolo Bianciardi, Guadalupe Miró, Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis Parasitology Research. ,vol. 105, pp. 155- 162 ,(2009) , 10.1007/S00436-009-1375-3

Simon L Croft, Shyam Sundar, Alan H Fairlamb, None, Drug Resistance in Leishmaniasis Clinical Microbiology Reviews. ,vol. 19, pp. 111- 126 ,(2006) , 10.1128/CMR.19.1.111-126.2006

Henning Lux, Norton Heise, Thomas Klenner, David Hart, Fred R. Opperdoes, Ether–lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether–lipid analogues in Leishmania Molecular and Biochemical Parasitology. ,vol. 111, pp. 1- 14 ,(2000) , 10.1016/S0166-6851(00)00278-4