Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity.

作者: Ashley J. Smuder

DOI: 10.1152/AJPREGU.00161.2019

关键词: PharmacologyCytotoxic T cellAnthracyclineToxicityChemistryChemotherapyAntitumor activityMitochondrionTreatment resultsDoxorubicin

摘要: Doxorubicin (DOX) is a highly effective antitumor agent used for the treatment of wide range cancers. Unfortunately, DOX results in cytotoxic side effects due to its accumulation wit...

参考文章(126)
K. C. Chen, H. Y. Lu, Chiung Chi Peng, R. Y. Peng, Treadmill exercise improved adriamycin-induced nephropathy Journal of Biological Regulators and Homeostatic Agents. ,vol. 26, pp. 15- 28 ,(2012)
E Fehrenbach, AM Niess, None, Role of heat shock proteins in the exercise response. Exercise Immunology Review. ,vol. 5, pp. 57- 77 ,(1999)
Linda K McLoon, J. Wirtschafter, G. Bauer, Quantification of muscle loss in the doxorubicin-treated orbicularis oculi of the monkey. Effect of local injection of doxorubicin into the eyelid. Investigative Ophthalmology & Visual Science. ,vol. 32, pp. 1667- 1673 ,(1991)
Pimprapa Vejpongsa, Edward T.H. Yeh, Prevention of Anthracycline-Induced Cardiotoxicity: Challenges and Opportunities Journal of the American College of Cardiology. ,vol. 64, pp. 938- 945 ,(2014) , 10.1016/J.JACC.2014.06.1167
Chia-Ying Lien, Brock T. Jensen, David S. Hydock, Reid Hayward, Short-term exercise training attenuates acute doxorubicin cardiotoxicity Journal of Physiology and Biochemistry. ,vol. 71, pp. 669- 678 ,(2015) , 10.1007/S13105-015-0432-X
Sandra M. Swain, Fredrick S. Whaley, Michael S. Ewer, Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer. ,vol. 97, pp. 2869- 2879 ,(2003) , 10.1002/CNCR.11407
VINCENT WS LEE, DAVID CH HARRIS, Adriamycin nephropathy: A model of focal segmental glomerulosclerosis Nephrology. ,vol. 16, pp. 30- 38 ,(2011) , 10.1111/J.1440-1797.2010.01383.X
Anna L. Schwartz, Fatigue mediates the effects of exercise on quality of life. Quality of Life Research. ,vol. 8, pp. 529- 538 ,(1999) , 10.1023/A:1008978611274
James H. Doroshow, Effect of Anthracycline Antibiotics on Oxygen Radical Formation in Rat Heart Cancer Research. ,vol. 43, pp. 460- 472 ,(1983)