Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies
作者： Danielle C. Chinn , William S. Holland , Philip C. Mack
DOI: 10.1007/S00432-014-1675-6
关键词: Aurora A kinase 、 Oncology 、 Lung cancer 、 Aurora kinase 、 Kinase 、 Biology 、 Aurora Kinase A 、 Internal medicine 、 Aurora inhibitor 、 Docetaxel 、 non-small cell lung cancer (NSCLC)
摘要: Purpose Aurora kinases are key regulators of mitotic events. Dysfunction these can cause polyploidy and chromosomal instability, a contributor to tumorigenesis. MK-5108 is potent inhibitor Aurora A kinase that has shown preclinical activity in malignancies breast, cervical, colon, ovarian, pancreatic origin. We sought assess the efficacy panel non-small-cell lung cancer cell lines as single agent combination with cisplatin docetaxel.
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