In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides.

摘要: A total of 60 clinical isolates Paracoccidioides brasiliensis were tested for susceptibility to sulfadiazine and sulfadimethoxyne by the agar dilution technique. modification Mueller-Hinton medium was devised which gave good growth yeast form. The minimum inhibitory concentrations only 51.6% in range recommended blood serum concentration (50 micrograms/ml). For 6 8% isolates, above 200 micrograms both per ml. significant decreases demonstrated one isolate obtained from a patient relapsing during sulfonamide therapy.