The Impact of Perioperative Blood Transfusion on Survival of Bladder Cancer Patients Submitted to Radical Cystectomy: Role of Anemia Status

摘要: Abstract Background The prognostic role of perioperative blood transfusion (PBT) in patients who underwent radical cystectomy (RC) for bladder cancer (BCa), although supported by clinical evidence, still remains to be assessed definitively. Objective To investigate the impact PBT on RC overall survival and after stratifying according preoperative anemia status define whether oncologic may assumed a primary effect or attributed reduced hemoglobin (Hb) level. Design, setting, participants A total 1490 consecutive with nonmetastatic BCa pelvic lymph node dissection between January 1990 August 2013 at single referral center entered study. Hb levels were statistically correlated postoperative outcomes. Outcome measurements statistical analysis Kaplan-Meier analyses used evaluate mortality (OM) cancer-specific (CSM). Multivariable Cox regression tested relationship risk OM CSM population severity their anemia. Results limitations 580 (38.9%) received PBT. Mean follow-up was 125.13 mo (median: 110 mo). Overall 5- 10-yr rates 58.3% 47.6%, respectively. At multivariable analyses, could not associated an increased either (all p > 0.3). Conversely, significantly (hazard ratio [HR]: 0.88; confidence interval [CI], 0.83–0.95) (HR: 0.84; 95% CI, 0.77–0.95) Conclusions In nonanemic proposed RC, is significant detrimental OM. This seems attributable direct PBT, regardless value. Patient summary cystectomy, negative should taken into account.