Brain-derived neurotrophic factor modulates cell excitability in the mouse medial nucleus of the trapezoid body.

摘要: Neurotrophins are a large class of trophic factors located throughout the central nervous system. While role neurotrophins in neuronal survival and axon guidance is well known, their secondary modulating synaptic transmission cell firing properties largely unexplored. In this study we examined expression mouse medial nucleus trapezoid body (MNTB) investigated effect exogenous brain-derived neurotrophic factor (BDNF) application on MNTB principal cells. The levels nerve growth factor, BDNF, neurotrophin-3, neurotrophin-4/5 major receptor tyrosine kinase B was found to be moderate high at postnatal day 12, indicating that may have following synaptogenesis. A 2-h exposure BDNF (100 ng/mL) had significant voltage-gated potassium currents. Importantly, preincubation increased incidence multifiring rebounding cells, significantly number action potentials fired response single depolarizing step. also decreased underlying currents, including both low- high-voltage-activated components. Our data show neurotrophins, specifically novel excitability auditory brainstem.