Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy

摘要: To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG). TiO2 nanocoral-like structures were synthesized by optimizing a solvothermal method. The nanocoral efficiently conjugated chemotherapeutic drugs on the surfaces of nanoparticles. mPEG multifunctional effectively and improved biocompatibility nanocorals. Following UV light irradiation, produce free radicals (˙OH ˙O2−) are effective for cells. Importantly, amount released from can be regulated UV-light irradiation time, which allows further control anti-cancer effect. exhibit combination light-activated, stimuli-triggered killing cell. cytotoxicity, cellular uptake, intracellular location formulations evaluated MCF7 Our results showed that nanocoral–DOX complexes exhibited greater cytotoxicity toward cells than DOX. work demonstrates therapeutic efficacy DOX-loaded is strongly dependent their loading mode effect under illumination, provides significant breakthrough future applications as activated carrier chemotherapy.