Laboratory infection of primates with Ascaris suum to provide a model of allergic bronchoconstriction.
作者： D. I. Pritchard , R. P. Eady , S. T. Harper , S. Trigg , I. M. Richards
DOI:
关键词: Antibody 、 Mast cell 、 Antigen 、 Immunoglobulin E 、 Ascaris 、 Immunology 、 Ascaris suum 、 Histamine 、 Biology 、 Eosinophilia
摘要: Wild-caught non-human primates are naturally sensitive to Ascaris antigen and provide a useful model for studying atopic asthma. The present study was carried out determine the effect of experimentally infecting home-bred macaques with nematode suum hence an alternative occurring model. Following oral infection parasite animals developed blood eosinophilia specific antibodies purified antigen. These appeared be IgE class as they could detected by radiometric assay using radiolabelled antibody human IgE. However, on further investigation, passive cutaneous anaphylaxis test, two classes were found, heat labile (56 degrees C) stable antibody. Lung lavage cells taken from monkeys infected shown include morphologically characteristic mast released histamine when challenged in vitro Hence this immediate hypersensitivity provides simple less accessible natural
参考文章(21)
K. Vendy, D. I. Pritchard, R. P. Eady, I. M. Richards, D. M. Jackson, T. S. C. Orr, E. Wells, Ascaris-induced bronchoconstriction in primates experimentally infected with Ascaris suum ova Clinical and Experimental Immunology. ,vol. 54, pp. 461- 468 ,(1983)
J. J. Pruzansky, R. Patterson, Y. Tomita, S. H. Oh, Irena M. Suszko, Respiratory mast cells and basophiloid cells. I. Evidence that they are secreted into the bronchial lumen, morphology, degranulation and histamine release. Clinical and Experimental Immunology. ,vol. 16, pp. 223- ,(1974)
Isaac Weiszer, Roy Patterson, J.J. Pruzansky, Ascaris hypersensitivity in the rhesus monkey Journal of Allergy. ,vol. 41, pp. 14- 22 ,(1968) , 10.1016/0021-8707(68)90004-X
Tarik I. Aljeboori, Michael H. Ivey, Toxocara canis infection in baboons. I. Antibody, white-cell, and serum-protein responses following infection. American Journal of Tropical Medicine and Hygiene. ,vol. 19, pp. 249- 254 ,(1970) , 10.4269/AJTMH.1970.19.249
R Patterson, I M Suszko, K E Harris, The in vivo transfer of antigen-induced airway reactions by bronchial lumen cells. Journal of Clinical Investigation. ,vol. 62, pp. 519- 524 ,(1978) , 10.1172/JCI109155
B. Uvnäs, J. K. Wold, Isolation of a mast cell degranulating polypeptide from Ascaris suis. Acta Physiologica Scandinavica. ,vol. 70, pp. 269- 276 ,(1967) , 10.1111/J.1748-1716.1967.TB03625.X
J.F. Williams, E.J.L. Soulsby, Antigenic analysis of developmental stages of Ascaris scum I. comparison of eggs, larvae and adults Experimental Parasitology. ,vol. 27, pp. 150- 162 ,(1970) , 10.1016/S0014-4894(70)80019-4
G. Mancini, A.O. Carbonara, J.F. Heremans, Immunochemical quantitation of antigens by single radial immunodiffusion Immunochemistry. ,vol. 2, pp. 235- 244 ,(1965) , 10.1016/0019-2791(65)90004-2
Michael A. Beaven, Sten Jacobsen, Zdenka Horáková, Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine Clinica Chimica Acta. ,vol. 37, pp. 91- 103 ,(1972) , 10.1016/0009-8981(72)90419-6
W.E. Parish, Short-term anaphylactic IgG antibodies in human sera. The Lancet. ,vol. 296, pp. 591- 592 ,(1970) , 10.1016/S0140-6736(70)90170-4