Dendritic cells in remodeling of lymph nodes during immune responses.

摘要: A critical hallmark of adaptive immune responses is the rapid and extensive expansion lymph nodes. During this process, complex internal structure organs maintained revealing existence mechanisms able to balance node integrity with structural flexibility. This article reviews architectural remodeling that occurs within nodes during how it regulated by dendritic cells (DCs). In particular we focus on previously unappreciated functions DCs in coordinating vasculature, fibroblastic reticular network maintenance lymphoid stromal phenotypes. Our increased understanding these processes indicates need be viewed not only as key antigen-presenting for lymphocytes but also broad-acting sentinels convey signals organ stroma thereby facilitate response initiation at multiple levels.