Immunogenicity of a locally produced hepatitis B vaccine with the birth dose stored outside the cold chain in rural Vietnam.
作者： DAVID B. HIPGRAVE , JAMES E. MAYNARD , NGUYEN THU VAN , HOANG THUY LONG , TRUNG NAM TRAN
DOI: 10.4269/AJTMH.2006.74.255
关键词: Vaccination 、 Immunogenicity 、 Antibody 、 Immunology 、 Cold chain 、 Hepatitis B vaccine 、 Antibody titer 、 Viral disease 、 Birth dose 、 Medicine
摘要: The heat stability of hepatitis B vaccine (HepB vaccine) should enable its storage outside the cold chain (OCC), increasing access to birth dose in areas lacking refrigeration. We compared immunogenicity a locally produced among infants who received three doses stored within (n = 358) or for whom first was OCC up one month 748). Serum collected from these at age 9-18 months. protective 80.3% all infants. There were no differences prevalence level antibody titer groups according strategy. Differences between certain could be explained by different vaccination schedules. Where coverage will improved, HepB can taken without affecting immunogenicity.
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