Clinical relevance of botulinum toxin immunogenicity.

作者： Reiner Benecke

DOI: 10.2165/11599840-000000000-00000

关键词: Antibody 、 Neutralizing antibody 、 Immunogenicity 、 Botulinum toxin 、 Neurotoxin 、 Immune system 、 Pharmacology 、 Microbiology 、 Neuromuscular junction 、 Clostridium botulinum 、 Biology

摘要: … by Clostridium botulinum, which … botulinum toxin complex contains a 150 kD neurotoxin together with a complex of up to six additional proteins. The neurotoxin is cleaved by clostridial …

参考文章(59)

Shashi Kant Sharma, Fen-Ni Fu, Bal Ram Singh, None, Molecular properties of a hemagglutinin purified from type A Clostridium botulinum. Journal of Protein Chemistry. ,vol. 18, pp. 29- 38 ,(1999) , 10.1023/A:1020691215056

Mark Hallett, Joseph Jankovic, Therapy with botulinum toxin M. Dekker. ,(1994)

C Shone, P Wilton-Smith, N Appleton, P Hambleton, N Modi, S Gatley, J Melling, Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay. Applied and Environmental Microbiology. ,vol. 50, pp. 63- 67 ,(1985) , 10.1128/AEM.50.1.63-67.1985

Iona Novak, L Campbell, M Boyce, VSC Fung, None, Botulinum toxin assessment, intervention and aftercare for cervical dystonia and other causes of hypertonia of the neck: international consensus statement European Journal of Neurology. ,vol. 17, pp. 94- 108 ,(2010) , 10.1111/J.1468-1331.2010.03130.X

G. Kranz, T. Sycha, B. Voller, G. S. Kranz, P. Schnider, E. Auff, NEUTRALIZING ANTIBODIES IN DYSTONIC PATIENTS WHO STILL RESPOND WELL TO BOTULINUM TOXIN TYPE A Neurology. ,vol. 70, pp. 133- 136 ,(2008) , 10.1212/01.WNL.0000287087.99612.E5

Frevert, Dressler, Complexing proteins in botulinum toxin type A drugs: a help or a hindrance? Biologics: Targets & Therapy. ,vol. 4, pp. 325- 332 ,(2010) , 10.2147/BTT.S14902

L. A. Koman, A. Brashear, S. Rosenfeld, H. Chambers, B. Russman, M. Rang, L. Root, E. Ferrari, J. Garcia de Yebenes Prous, B. P. Smith, C. Turkel, J. M. Walcott, P. T. Molloy, Botulinum Toxin Type A Neuromuscular Blockade in the Treatment of Equinus Foot Deformity in Cerebral Palsy: A Multicenter, Open-Label Clinical Trial Pediatrics. ,vol. 108, pp. 1062- 1071 ,(2001) , 10.1542/PEDS.108.5.1062

Roshan Kukreja, Tzuu-Wang Chang, Shuowei Cai, Paul Lindo, Stephen Riding, Yu Zhou, Easwaran Ravichandran, Bal Ram Singh, Immunological characterization of the subunits of type A botulinum neurotoxin and different components of its associated proteins Toxicon. ,vol. 53, pp. 616- 624 ,(2009) , 10.1016/J.TOXICON.2009.01.017

Jürgen Frevert, Xeomin is free from complexing proteins. Toxicon. ,vol. 54, pp. 697- 701 ,(2008) , 10.1016/J.TOXICON.2009.03.010

Daniel Truong, Matthew Brodsky, Mark Lew, Allison Brashear, Joseph Jankovic, Eric Molho, Olga Orlova, Sofia Timerbaeva, Global Dysport Cervical Dystonia Study Group, Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia Parkinsonism & Related Disorders. ,vol. 16, pp. 316- 323 ,(2010) , 10.1016/J.PARKRELDIS.2010.03.002