Urokinase-Behandlung der Phlegmasia coerulea dolens*

摘要: Fibrinolysis treatment with urokinase was successfully undertaken in two patients, aged 71 and 76 years, phlegmasia coerulea dolens. In the first case, necrosis fore-foot, there significant regression of necrotic area, but a later limited amputation still necessary. second, severe heart failure, recurrent pulmonary emboli hyperosmolar uncontrolled diabetes mellitus, complete healing achieved. Venous thrombectomy not possible these patients because duration thrombosis veins pelvic region, had already occurred, patients' general condition so serious. The advanced age arteriosclerotic changes argued against streptokinase treatment. Mean maintenance dosage 1000-1500 IU/kg X h, simultaneous administration heparin at about 20 U/kg produced no side-effects. Minor gastro-intestinal bleeding did require stoppage administration.