Pharmacogenetics of Angiogenesis

摘要: Angiogenesis is a complex cascade of events involving extensive interplay between cells, soluble factors, and extracellular matrix components. Soluble factors including cytokines growth have multifaceted stimulatory or inhibitory roles, thereby finely tuning the process. The angiogenic potential tumors was initially demonstrated in animal models, it now recognized that angiogenesis not only precedes tumor but also necessary for metastasis. Vascular endothelial factor (VEGF) plays central role prostate angiogenesis. Genetic variability VEGF involves mainly untranslated region gene may be associated with increased transcription protein expression. Indeed, -1154G>A polymorphism increases has been significantly risk cancer. Hypoxia inducible factor-1α (HIF-1α) overexpressed early stage cancer; through its binding to hypoxic responsive elements, activates wide variety genes as part cellular response hypoxia, VEGF, potentially key cancer development antiangiogenic drugs. Therefore, angiogenesis-related seem an important aggressiveness, thus influencing outcome treatments survival patients.