Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective.

摘要: Sensitization to perennial aeroallergens correlates with the risk of persistent asthma (AS) in children. In tropical Singapore, multiple codominant species mites abound indoor environment, and preferential species-specific sensitization has been associated different phenotypes allergic disease. We investigated pattern mite component-specific IgE (mcsIgE) children clinical disease an environment exposure. A prospective evaluation newly diagnosed patients diagnosis rhinitis (AR), atopic dermatitis (AD), or AS one more were performed. Sera tested for specific against extensive panel Dermatophagoides pteronyssinus Blomia tropicalis allergens. total 253 included, mean age 7.3 yr, 79% fulfilled criteria AR, 46% AS, 71% AD, 31% all three. both was observed 91% children, 89% sensitized D. pteronyssinus, 70% B. tropicalis. The most common allergens recognized by these Der p 1 (64%), 2 (71%), Blo t 5 (45%), 7 (44%), 21 (56%). Specific responses increased number distinct correlated complexity phenotype. multivariate analysis, multi-systemic phenotype (AR + AD) repertoire components (three more) (OR 4.3, 95% CI 2.1-8.8, = 0.001) a positive parental history 2.4, 1.2-2.9, 0.013). highly pleiomorphic response prevalent is presence childhood environment.