Mechanical and structural properties of different types of human aortic atherosclerotic plaques

摘要: Abstract Atherosclerotic plaques are characterized by structural heterogeneity affecting aortic behaviour under mechanical loading. There is evidence of direct connections between the plaque arrangement and risk rupture. As a consequence rupture, components transferred bloodstream to smaller vessels, resulting in acute cardiovascular events with poor prognosis, such as heart attacks or strokes. Hence, evaluation composition, structure, biochemical profile atherosclerotic seems be great importance assess properties mechanically induced failure, indicating strength rupture vulnerability plaque. The main goal research was determine experimentally uniaxial loading different types human abdominal aorta identified based on vibrational spectra (ATR-FTIR FT-Raman spectroscopy) analysis validated histological staining. potential spectroscopic techniques useful histopathological tool demonstrated. Three – predominantly calcified (APC), lipid (APL), fibrotic (APF) were distinguished confirmed examinations. Compared normal aorta, stiffer (median EH for circumferential axial directions, respectively: 8.15 MPa 6.56 MPa) stronger σM APLc = 1.57 MPa APLa = 1.64 MPa), lipidic weakest APLc = 0.76 MPa APLa = 0.51 MPa), stiffest 13.23 MPa 6.67 MPa). Therefore, detected most prone rupture; however, failure process reflected simplification stress-stretch characteristics vary depending composition.