Folate and Fetal Growth

摘要: Folate is a water-soluble B vitamin that essential for various one-carbon transfer reactions including formate oxidation, amino acid metabolism, and biosynthesis of thymidylate purines. The term “folate” represents all folate derivatives, its synthesized form, pteroylglutamic (folic acid, FA). In humans, known to be absorbed from the upper-small intestine. bioavailability FA estimated 1.7 times higher than natural food folate. recent years, has received enthusiastic attention because preventive effects on fetal neural tube defects if given periconceptionally. addition, became one hottest nutrients research interest in last two decades, since elevated serum or plasma homocysteine been implicated as risk factor occlusive vascular disease, metabolism closely regulated by Although we need understand intricate metabolic changes associated with human pregnancy, do know requirement increases during pregnancy support growth. To meet this increased demand, actively transferred fetus across placenta. findings many studies are inconsistent terms association birthweight (considered best assessment growth) maternal dietary intake, biomarkers status, effect supplementation. We suggest systematic well-designed performed better critical period adequate status achieve optimal