Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience.
作者： M Lishner , R Feld , D G Payne , U Sagman , J P Sculier
关键词: Lung cancer 、 Surgery 、 Vincristine 、 Hearing loss 、 Conventional PCI 、 Prophylactic cranial irradiation 、 Radiation therapy 、 Medicine 、 Metastasis 、 Weakness
摘要: We retrospectively analyzed the charts of 58 long-term survivors small-cell lung cancer (SCLC) (greater than 2 years) for neurological complications and their impact on well-being these patients. also attempted to have patients complete a questionnaire regarding any possible problems. This was done in 14 Metastasis CNS occurred significantly less often who received prophylactic cranial irradiation (PCI) dose 20 Gy five equal fractions (two 48), compared with did not receive it (four 10) (P .006). Delayed nine 48 (19%) PCI. However, only two PCI appear be responsible progressive dementia. In other seven (one weakness arms legs, one transient left hemiparesis, hearing loss, three various visual disturbances), chemotherapeutic agents (mainly cisplatin vincristine) underl...
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