Bright's Disease Today: The Pathogenesis and Treatment of Glomerulonephritis—I

摘要: Since Bright9s day the study of glomerulonephritis has largely consisted in observation clinical, biochemical, and morphological characteristics patients. Linked to this been attempt name classify these data a fashion which improved prediction outcome response treatment. This proved difficult, since there is no absolute correspondence between clinical syndromes findings kidney. The histological have, however, allowed good prognosis response. We now have enough information from experimental models nephritis outline pathogenesis glomerulonephritis. Immune mechanisms are certainly concerned some patients, role chronic soluble complex deposition kidney being particulary important. Non-immunological origins mediation injury, at least as Injury glomerulus mediated through interaction complement coagulation mechanisms, leading release factors inflammation. Repair probably central producing irreversible glomerular damage. Treatment can be directed towards events nephritis, most accessible moment immediate mediators injury. At more fundamental level better identification individual patients injury needed, such isolation, avoidance, or elimination antigens involved disease. Laboratory techniques begin investigations man available need applied widely field with