Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

摘要: An increasing amount of information on the action antimicrobial peptides (AMPs) at molecular level has not yet been translated into a comprehensive understanding effects in bacteria. Although some biophysical attributes AMPs have correlated with macroscopic features, physiological relevance other properties addressed. Pertinent and surprising conclusions therefore left unstated. Strong membrane-binding micromolar therapeutic concentrations indicate that membrane-bound may be reached are higher than intuitively expected, triggering disruptive