Epidemiology of Foot and Mouth Disease in Cattle in Pahang, Malaysia

摘要: Foot-and-mouth disease (FMD) is one of the most contagious diseases domestic and wild cloven-hoofed animals. The has a significant negative impact on economy affected countries through reduced livestock productivity loss markets. In Pahang, Malaysia severe outbreak FMD started in December 2003, after approximately 18 years freedom from disease. FMDV strain O was identified as cause this outbreak. study reported thesis focused three areas epidemiology designed to: determine temporal spatial distribution pattern outbreaks Pahang; identify risk factors associated with occurrence antibody response local cattle following vaccination against FMD. Although adopted control measure for findings indicated that only half (56%) respondents believed preventive 37.3% correctly explaining how spreads. Unfortunately 29% knew vaccine needed to be given at six monthly intervals no second priming dose required administered month primary dose. Antibody conferred significantly higher animals which had been multiply vaccinated than received their first vaccination. There evidence stimulated serological immunity; however immunity, many cases, not sufficient protect against natural infection. addition NSP test 7 (5 cows 2 calves) were positive during eleven period, although clinical ever seen farm. Three variables (factors) found Pahang multivariable logistic regression analysis. strongly factor retaining seropositive herd (P =0.006; OR=3.62; 95% CI 1.44, 9.11). Cattle farmers who kept other more likely (P=0.003; OR 3.2; 1.47, 7.07) have an infected owners didn’t keep species livestock. Farmers allowed entry unauthorised vehicles onto farmland also (P=0.05; = 2.2; 1.0, 4.82). The spatio-temporal period 16th 2003 26th August 2006 assessed using Space – Time permutation model. This there five distinctive clusters geographical overlap secondary whole period. Clusters east, west middle observed expected ratio within being between 2.39 17.78. appeared seasonal occurring rainy season coincided “Hari Raya Korban” when live are moved throughout country. present provided valuable information development effective eradication program state Malaysia.