Gabaergic stimulation inhibits central actions of angiotensin II: Pressor responses, drinking and release of vasopressin

摘要: Abstract In conscious rats, intracerebroventricular (i.c.v.) treatment with the GABA agonist muscimol (1–100 ng) suppressed pressor responses to ANG II (100 ng i.c.v.) in a dose-dependent and reversible fashion. Treatment i.c.v. (1–500 μg) produced similar but shorter inhibition. Inhibition of endogenous degradation amino-oxyacetic acid (AOAA, 30 mg/kg i.p.) markedly reduced (10–1000 recovery period 24 h. This inhibition was reversed by antagonist bicuculline (1 μg i.c.v.). Muscimol did not significantly attenuate histamine (10 μg). Pretreatment drastically drinking (500 increased latency drink. also induced carbachol (50 inhibited i.c.v.)-induced release AVP from pituitary gland complete suppression response at highest dose. Our results demonstrate that GABAergic system exerts an inhibitory control on pathways mediating various central actions II, which appears be most specific for II-induced responses.