RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop
作者： Nis David Giladi , Amotz Ziv-Av , Hae Kyung Lee , Susan Finniss , Simona Cazacu
关键词: Epithelial–mesenchymal transition 、 Stem cell 、 Glioma 、 Mesenchymal stem cell 、 Neural stem cell 、 Transfection 、 Biology 、 Gene silencing 、 STAT3 、 Molecular biology 、 Cancer research
摘要: Glioblastomas (GBMs), the most aggressive primary brain tumors, exhibit increased invasiveness and resistance to anti-tumor treatments. We explored role of RTVP-1, a glioma-associated protein that promotes glioma cell migration, in mesenchymal transformation GBM. Analysis The Cancer Genome Atlas (TCGA) demonstrated RTVP-1 expression was higher GBM predicted tumor recurrence poor clinical outcome. ChiP analysis revealed promoter binds STAT3 C/EBPβ, two master transcription factors regulate In addition, IL-6 induced STAT3-dependent manner. migration cells. Similarly, overexpression human neural stem cells differentiation, whereas silencing (GSCs) decreased stemness these Silencing also survival mice bearing GSC-derived xenografts. Using gene array silenced we identified as mediator effects on GSCs, therefore acting positive feedback loop by upregulating via pathway. Collectively, results implicate novel prognostic marker therapeutic target
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