TCRβ Combinatorial Immunoreceptor Expression by Neutrophils Correlates with Parasite Burden and Enhanced Phagocytosis during a Plasmodium berghei ANKA Malaria Infection.
作者： Joanna K. Chorazeczewski , Maya Aleshnick , Victoria Majam , Winter A. Okoth , Regina Kurapova
DOI: 10.1128/IAI.00899-17
关键词: T-cell receptor 、 Immunology 、 Integrin alpha M 、 Phagocytosis 、 Spleen 、 Biology 、 Receptor expression 、 Plasmodium berghei 、 Trogocytosis 、 Recombination-activating gene
摘要: Recent studies have demonstrated that a subpopulation of neutrophils express the TCRαβ combinatorial immunoreceptor in humans and mice. Here, we report Plasmodium berghei ANKA murine malaria infection induces expansion TCRβ expressing CD11b+ Ly6G+ spleen during early phase infection. Measurement transcript protein levels wild-type versus nude Rag1 knockout mice establishes observed expression is not consequence nonspecific antibody staining or passive receptor due to phagocytosis trogocytosis peripheral T cells. Remarkably, on day 3 postinfection, highly significant correlation between proportion blood parasite burden. In addition, TCRβ+ phagocytose parasitized erythrocytes with 4-fold greater efficiency than TCRβ- neutrophils. Together these results signify TCR by neutrophil plays an important role regulation burden enhancing phagocytic capacity neutrophil.
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