NMDA and AMPA receptors on neocortical neurons are differentially distributed
作者： H. -U. Dodt , A. Frick , K. Kampe , W. Zieglgänsberger
DOI: 10.1046/J.1460-9568.1998.00338.X
关键词: Neuroscience 、 Kainate receptor 、 NMDA receptor 、 AMPA receptor 、 Long-term depression 、 Dendritic spine 、 Neocortex 、 Silent synapse 、 Chemistry 、 Proximal dendrite
摘要: The distribution of glutamate receptor subtypes on the surface neurons is highly relevant for synaptic activation and signal processing in neocortex. As a novel approach we have used infra-red videomicroscopy combination with photostimulation or microiontophoresis brain slices rat neocortex to map N-methyl-D-aspartate (NMDA) alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors pyramidal layer V. Both modes application revealed spatially distinct subtypes: soma proximal dendrite are sensitive NMDA, whereas more distal parts AMPA. An implication that NMDA near might regulate amplification signals resulting from AMPA remote dendritic sites.
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