Roles for KRAS in Pancreatic Tumor Development and Progression
作者： Marina Pasca Di Magliano , Craig D Logsdon , None
DOI: 10.1053/J.GASTRO.2013.01.071
关键词: Cancer research 、 Pancreatic cancer 、 Biomarker (medicine) 、 Cancer genome sequencing 、 KRAS 、 Pancreatic Intraepithelial Neoplasia 、 Oncogene 、 Biology 、 Disease 、 Pancreatic tumor
摘要: The Kras gene is mutated to an oncogenic form in most pancreatic tumors. However, early attempts use this molecule as a specific biomarker of the disease, or inhibit its activity cancer therapy, failed. This left situation which everyone was aware association between important oncogene and cancer, but no one knew what do about it. Recent findings have changed picture—many assumptions made KRAS role were found be incorrect. Several factors contributed increased understanding activities KRAS, including creation genetically engineered mouse models, allowed for detailed analyses carcinogenesis intact animal with competent immune system. Cancer genome sequencing projects our heterogeneity individual We also better oncogenes are tumor maintenance therefore called “drivers.” review advances limitations knowledge development cancers areas future research.
gastrojournal.org
gastro.org
elsevier.com参考文章(82)
Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Eric S. Martin, Jeffery Chang, Aram F. Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Lynda Chin, Lewis C. Cantley, Ronald A. DePinho, Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism Cell. ,vol. 149, pp. 656- 670 ,(2012) , 10.1016/J.CELL.2012.01.058
Dominico Vigil, Jacqueline Cherfils, Kent L. Rossman, Channing J. Der, Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nature Reviews Cancer. ,vol. 10, pp. 842- 857 ,(2010) , 10.1038/NRC2960
Lynda Elghazi, Aaron J. Weiss, Daniel J. Barker, John Callaghan, Lora Staloch, Eric P. Sandgren, Maureen Gannon, Volkan N. Adsay, Ernesto Bernal–Mizrachi, Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling Gastroenterology. ,vol. 136, pp. 1091- 1103 ,(2009) , 10.1053/J.GASTRO.2008.11.043
Anupam Patgiri, Kamlesh K Yadav, Paramjit S Arora, Dafna Bar-Sagi, An orthosteric inhibitor of the Ras-Sos interaction Nature Chemical Biology. ,vol. 7, pp. 585- 587 ,(2011) , 10.1038/NCHEMBIO.612
Carmen Guerra, Nieves Mijimolle, Alma Dhawahir, Pierre Dubus, Marta Barradas, Manuel Serrano, Victoria Campuzano, Mariano Barbacid, Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context Cancer Cell. ,vol. 4, pp. 111- 120 ,(2003) , 10.1016/S1535-6108(03)00191-0
Mitsuro Kanda, Hanno Matthaei, Jian Wu, Seung–Mo Hong, Jun Yu, Michael Borges, Ralph H. Hruban, Anirban Maitra, Kenneth Kinzler, Bert Vogelstein, Michael Goggins, Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia Gastroenterology. ,vol. 142, pp. 730- 733.e9 ,(2012) , 10.1053/J.GASTRO.2011.12.042
N. Bardeesy, A. J. Aguirre, G. C. Chu, K.-h. Cheng, L. V. Lopez, A. F. Hezel, B. Feng, C. Brennan, R. Weissleder, U. Mahmood, D. Hanahan, M. S. Redston, L. Chin, R. A. DePinho, Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 5947- 5952 ,(2006) , 10.1073/PNAS.0601273103
David M. Berman, Sunil S. Karhadkar, Anirban Maitra, Rocio Montes de Oca, Meg R. Gerstenblith, Kimberly Briggs, Antony R. Parker, Yutaka Shimada, James R. Eshleman, D. Neil Watkins, Philip A. Beachy, Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature. ,vol. 425, pp. 846- 851 ,(2003) , 10.1038/NATURE01972
Meredith A. Collins, Jean-Christophe Brisset, Yaqing Zhang, Filip Bednar, Josette Pierre, Kevin A. Heist, Craig J. Galbán, Stefanie Galbán, Marina Pasca di Magliano, Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice PLoS ONE. ,vol. 7, pp. e49707- ,(2012) , 10.1371/JOURNAL.PONE.0049707
Catherine Carrière, Alison L. Young, Jason R. Gunn, Daniel S. Longnecker, Murray Korc, Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras Biochemical and Biophysical Research Communications. ,vol. 382, pp. 561- 565 ,(2009) , 10.1016/J.BBRC.2009.03.068