The future of male contraception: a fertile ground.

摘要: The continued and rapid expansion of the Earth's population mandates need for safe effective measures contraception. While a plethora options exist women, methods contraception male partner are limited to condoms vasectomy. sequela this discrepancy has led family planning burden falling disproportionately on female partner. For past several decades, extensive research been undertaken exploring feasibility hormonal This proposed method focused suppressing spermatogenesis by exploiting hypothalamic-pituitary-gonadal (HPG) axis. Beginning with proof concept studies in early nineties, administration testosterone healthy subjects shown be an efficacious inducing sterility. Owing ethnic differences suppression comparatively low rate azoospermia Caucasian men androgen-only regimens, investigators have explored addition progestins further enhance efficacy Though revealed promise androgen-progestin lack long-term precluded development marketable product. Recently, more directed towards identifying non-hormonal alternatives These ranged from devices facilitating reversible occlusion vas deferens lumen medications disrupting various pathways process spermatogenesis. Underlying strategies is shared enthusiasm women these methods. willingness couples pursue combined global reduce psychological socioeconomic implications unintended pregnancy ensures that will continue bring goal fruition.